Biliary Tract Microbiota Similarities in Pancreatic Ductal Adenocarcinoma

Ariel A. Arteta, Miryan Sánchez-Jiménez, Nora Cardona-Castro


Objective: to analyze microbiota profiles in the biliary tract, of pancreatic ductal adenocarcinoma (PDAC) patients and gallstones patients, in order to identify differences, which may contribute to a better understanding of PDAC carcinogenesis. Methods: using microbiota analysis, a total of 25 samples from 14 patients were collected during surgery and compared. Samples were divided into three groups; one GS group (N = 3), and two PDAC groups; PDAC gallbladder group (N = 11) and PDAC brush group (N = 11). Results: upon comparison of bacterial communities’ alpha and beta diversity indices and relative abundances by group (anatomic site) and condition (GS vs PDAC), we found no statistically significant results. However, we can highlight the high similarity of the compared parameters among the two different anatomic locations over the biliary tract in PDAC patients. Conclusion: to the best of our knowledge, this is the first study comparing two different anatomic locations over the biliary tract in PDAC patients. Among PDAC groups microbiota along the semi-closed duct system of the biliary tract showed substantial similarity, reflected in the alpha and beta diversity indices and relative abundances.

Palabras clave

Pancreatic cancer, microbiota, bile, biliary tract microbiota

Texto completo:

PDF (English)


Enlaces refback

  • No hay ningún enlace refback.

Kra 15 N 118-03 oficina 503, Bogotá D.C., ColombiaTeléfonos: 215 37 14 - 215 35 17 Infectio es una publicación científica, órgano oficial de la Asociación Colombiana de Infectología, ACIN. La revista no se responsabiliza por los criterios expresados por sus autores.; La Revista Infectio se encuentra indexada en Scielo, Flying Publisher, Publimdex, Imbiomed, Doaj, Lilacs