Eritema Nodoso Leproso: Reporte de un caso pediátrico tratado exitosamente con talidomida

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Publicado: sep 12, 2024
DOI: https://doi.org/10.22354/24223794.1192
Palabras clave:
Lepra, Mycobacterium leprae, Talidomida

Contenido principal del artículo

Natalia Delgado
Pediatric Resident, Department of Pediatrics, Universidad Surcolombiana, Neiva
https://orcid.org/0000-0002-5041-387X
Jalil Rashid Forero
Pediatric Resident, Department of Pediatrics, Universidad Surcolombiana, Neiva
https://orcid.org/0009-0008-7968-1123
Pilar Pérez
Pediatric Rheumatologist, Department of Pediatrics, Universidad Surcolombiana. Department of Pediatrics, Hospital Universitario de Neiva
https://orcid.org/0000-0002-4756-6808
Rolando Rios
Pediatric Nephrologist, Department of Pediatrics, Universidad Surcolombiana. Department of Pediatrics, Hospital Universitario de Neiva
https://orcid.org/0009-0003-9928-1649
Doris M. Salgado
Professor, Department of Pediatrics, Universidad Surcolombiana, Neiva
https://orcid.org/0000-0002-1663-1996
Andres Felipe Romero
Pediatric infectious diseases specialist, Department of Pediatrics, Univer sidad Surcolombiana. Department of Pediatrics, Hospital Universitario de Neiva.
https://orcid.org/0000-0002-4124-5982

Resumen

Presentamos el caso de un paciente de 10 años quien consulta a urgencias por presentar fiebre prolongada, múltiples lesiones nodulares en piel y reporte de paraclínicos que confirmaban lepra. Como complicación, presenta una reacción leprosa tipo 2 que no respondió de manera adecuada a esteroides sistémicos, por lo cual usamos talidomida, un medicamento poco usado en niños, pero con el cual logramos controlar la respuesta inflamatoria.

Detalles del artículo

Número
VOL. 28. NUM 3. (2024)
Sección
Reporte del caso

Citas

H. Serrano-Coll, H. R. Mora, J. C. Beltrán, M. S. Duthie, and N. Cardona Castro, "Social and environmental conditions related to Mycobacterium leprae infection in children and adolescents from three leprosy endemic regions of Colombia," BMC Infect. Dis., vol. 19, no. 1, pp. 1-10, 2019. https://doi.org/10.1186/s12879-019-4120-2

S. S. Bandeira, C. A. Pires, and J. A. S. Quaresma, "Leprosy reactions in childhood: A prospective cohort study in the Brazilian amazon," Infect. Drug Resist., vol. 12, pp. 3249-3257, 2019. https://doi.org/10.2147/IDR

World Health Organization, "Leprosy (Hansen's disease)," Leprosy (Hansen's disease), 2023. [Online]. Available: https://www.who.int/data/gho/data/themes/topics/leprosy-hansens-disease.

C. L. P. Clavijo, "LEPRA INFORME DE EVENTO INSTITUTO NACIONAL DE SALUD," 2021. [Online]. Available: https://www.ins.gov.co/buscador eventos/Informesdeevento/LEPRA PE VI 2021.pdf. [Accessed: 18-Oct 2021].

N. Cardona-Castro, "Leprosy in Colombia," Curr. Trop. Med. Reports, vol. no. 2, pp. 85-90, 2018. https://doi.org/10.1007/s40475-018-0145-7

M. B. B. de Oliveira and L. M. Diniz, "Leprosy among children under 15 years of age: Literature review," An. Bras. Dermatol., vol. 91, no. 2, pp. 196-203, 2016. https://doi.org/10.1590/abd1806-4841.20163661

C. Beltrán-Alzate et al., "Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country," PLoS Negl. Trop. Dis., vol. 10, no. 10, pp. 1-12, 2016. https://doi.org/10.1371/journal.pntd.0005041

P. Thangaraju, S. Venkatesan, M. Gurunthalingam, S. Babu, and T. Tamilselvan, "Rationale use of thalidomide in erythema nodosum leprosum-a non-systematic critical analysis of published case reports," Rev. Soc. Bras. Med. Trop., vol. 53, pp. 1-9, 2020. https://doi.org/10.1590/0037-8682-0454-2019

WHO, "Guidelines for the Diagnosis, Treatment and Prevention of Leprosy," Oms, pp. 1-87, 2018.

I. M. Romero-Montoya, J. C. Beltrán-Alzate, D. C. Ortiz-Marín, A. Diaz-Diaz, and N. Cardona-Castro, "Leprosy in colombian children and adolescents," Pediatr. Infect. Dis. J., vol. 33, no. 3, pp. 321-322, 2013. https://doi.org/10.1097/INF.0000000000000057

V. S. Santos, L. C. Santos, L. V. R. Lôbo, L. M. D. Lemos, R. Q. Gurgel, and L. E. Cuevas, "Leprosy and disability in children younger than 15 years in an endemic area of Northeast Brazil," Pediatr. Infect. Dis. J., vol. 34, no. 3, pp. e44-e47, 2015. https://doi.org/10.1097/INF.0000000000000592

R. R. Castillo et al., "Leprosy in children in cuba: Epidemiological and clinical description of 50 cases from 2012-2019," PLoS Negl. Trop. Dis., vol. 15, no. 10, pp. 1-13, 2021. https://doi.org/10.1371/journal.pntd.0009910

A. Pulido-Pérez, M. D. Mendoza-Cembranos, J. A. Avilés-Izquierdo, and R. Suárez-Fernández, "Eritema nudoso leproso y reacción de reversión en 2 casos de lepra importada," Actas Dermosifiliogr., vol. 104, no. 10, pp. 915-919, 2013. https://doi.org/10.1016/j.ad.2012.09.009

D. P. Legendre, C. A. Muzny, and E. Swiatlo, "Hansen's disease (Leprosy): Current and future pharmacotherapy and treatment of disease-related immunologic reactions," Pharmacotherapy, vol. 32, no. 1, pp. 27-37, 2012. https://doi.org/10.1002/PHAR.1009

B. Upputuri, M. S. Pallapati, P. Tarwater, and A. Srikantam, "Thalidomide in the treatment of erythema nodosum leprosum (ENL) in an outpatient setting: A five-year retrospective analysis from a leprosy referral centre in India," PLoS Negl. Trop. Dis., vol. 14, no. 10, pp. 1-13, 2020. https://doi.org/10.1002/PHAR.1009

P. do S. S. Costa, L. R. Fraga, T. W. Kowalski, E. L. R. Daxbacher, L. Schuler Faccini, and F. S. L. Vianna, "Erythema Nodosum Leprosum: Update and challenges on the treatment of a neglected condition," Acta Trop., vol. 183, pp. 134-141, 2018. https://doi.org/10.1016/j.actatropica.2018.02.026