In memoriam: Profesor Manuel Elkin Patarroyo Murillo (1942-2025): Lecciones de su legado monumental para la ciencia colombiana y latinoamericana

Del Portillo P, Murillo LA, Patarroyo ME. Amplification of a species-specific DNA fragment of Mycobacterium tuberculosis and its possible use in diagnosis. J Clin Microbiol 1991;29:2163-8. https://doi.org/10.1128/jcm.29.10.2163-2168.1991

Patarroyo ME, Molina E, Londono F, Bernal D, Caro L, Velasques A, et al. Identification of a particular B cell alloantigen associated with susceptibility to lepromatous leprosy. Lepr Rev 1981;52:121-35. https://doi.org/10.5935/0305-7518.19810064.

Agudelo WA, Patarroyo ME. Quantum Chemical Analysis of MHC-Peptide Interactions for Vaccine Design. Mini-Reviews in Medicinal Chemistry 2010;10:746-58. https://doi.org/10.2174/138955710791572488

Ortiz-Mahecha CA, Agudelo WA, Patarroyo MA, Patarroyo ME, Suárez CF. MHCBI: A pipeline for calculating peptide-MHC binding energy using semi-empirical quantum mechanical methods with explicit/implicit solvent models. Brief Bioinform 2021;22. https://doi.org/10.1093/BIB/BBAB171.

Patarroyo ME, Patarroyo MA. Emerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccines. Acc Chem Res 2008;41:377-86. https://doi.org/10.1021/ar700120t

Benítez-Páez A, Cárdenas-Brito S. Bioinformática en Colombia: presente y futuro de la investigación biocomputacional. Biomédica 2010;30:170-7. https://doi.org/10.7705/biomedica.v30i2.180

Vizcaíno C, Restrepo-Montoya D, Rodríguez D, Niño LF, Ocampo M, Vanegas M, et al. Computational prediction and experimental assessment of secreted/surface proteins from Mycobacterium tuberculosis H37Rv. PLoS Comput Biol 2010;6:1-14. https://doi.org/10.1371/journal.pcbi.1000824

Restrepo-Montoya D, Vizcaíno C, Niño LF, Ocampo M, Patarroyo ME, Patarroyo MA. Validating subcellular localization prediction tools with mycobacterial proteins. BMC Bioinformatics 2009;10. https://doi.org/10.1186/1471-2105-10-134.

Restrepo-Montoya D, Becerra D, Carvajal-Patiño JG, Mongui A, Niño LF, Patarroyo ME, et al. Identification of plasmodium vivax proteins with potential role in invasion using sequence redundancy reduction and profile hidden Markov models. PLoS One 2011;6. https://doi.org/10.1371/journal.pone.0025189

Moreno-Pérez DA, Patarroyo MA. Inferring Plasmodium vivax protein biology by using omics data. J Proteomics 2020;218. https://doi.org/10.1016/J.JPROT.2020.103719

Bermúdez M, Arévalo-Pinzón G, Rubio L, Chaloin O, Muller S, Curtidor H, et al. Receptor-ligand and parasite protein-protein interactions in Plasmodium vivax: Analysing rhoptry neck proteins 2 and 4. Cell Microbiol 2018;20. https://doi.org/10.1111/cmi.12835

Cubides JR, Camargo-Ayala PA, Niño CH, Garzón-Ospina D, Ortega Ortegón A, Ospina-Cantillo E, et al. Simultaneous detection of Plasmodium vivax dhfr, dhps, mdr1 and crt-o resistance-associated mutations in the Colombian Amazonian region. Malar J 2018;17. https://doi.org/10.1186/S12936-018-2286-5

Hernández EC, Suárez CF, Parra CA, Patarroyo MA, Patarroyo ME. Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae). Tissue Antigens 2005;66:640-9. https://doi.org/10.1111/j.1399-0039.2005.00491.x

Baquero JE, Miranda S, Murillo O, Mateus H, Trujillo E, Suarez C, et al. Reference strand conformational analysis (RSCA) is a valuable tool in identifying MHC-DRB sequences in three species of Aotus monkeys. Immunogenetics 2006;58:590-7. https://doi.org/10.1007/s00251-006-0101-x

López C, Suárez CF, Cadavid LF, Patarroyo ME, Patarroyo MA. Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini). PLoS One 2014;9. https://doi.org/10.1371/JOURNAL.PONE.0096973

Salazar LM, Bermúdez A, Patarroyo ME. HLA-DR allele Reading register shifting is associated with immunity induced by SERA peptide analogues. Biochem Biophys Res Commun 2008;372:114-20. https://doi.org/10.1016/J.BBRC.2008.04.186

Patarroyo ME, Cifuentes G, Baquero J. Comparative molecular and three dimensional analysis of the peptide-MHC II binding region in both human and Aotus MHC-DRB molecules confirms their usefulness in antimalarial vaccine development. Immunogenetics 2006;58:598-606. https://doi.org/10.1007/s00251-006-0128-z

Patarroyo ME, Romero P, Torres ML, Clavijo P, Moreno A, Martínez A, et al. Induction of protective immunity against experimental infection with malaria using synthetic peptides. Nature 1987 328:6131 1987;328:629-32. https://doi.org/10.1038/328629a0

Patarroyo ME, Amador R, Clavijo P, Moreno A, Guzman F, Romero P, et al. A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria. Nature 1988;332:158-61. https://doi.org/10.1038/332158a0

Valero M V., Amador LR, Galindo C, Figueroa J, Bello MS, Murillo LA, et al. Vaccination with SPf66, a chemically synthesised vaccine, against Plasmodium falciparum malaria in Colombia. Lancet 1993;341:705-10. https://doi.org/10.1016/0140-6736(93)90483-W

Snounou G, Rénia L. The vaccine is dead - long live the vaccine. Trends Parasitol 2007;23:129-32. https://doi.org/10.1016/j.pt.2007.02.001

Graves PM, Gelband H. Vaccines for preventing malaria (SPf66). Cochrane Database Syst Rev 2006;2006. CD005966 https://doi.org/10.1002/14651858

Alonso P. Patarroyo, una fuerza de la naturaleza que polarizó a la comunidad científica | Salud y bienestar | EL PAÍS. El Pais 2025. https://elpais.com/salud-y-bienestar/2025-01-11/patarroyo-una-fuerza-de la-naturaleza-que-polarizo-a-la-comunidad-cientifica.html (accessed February 1, 2025).

Moreno A, Patarroyo M. Development of an asexual blood stage malaria vaccine. Blood 1989;74:537-46. V74.2.537.53 https://doi.org/10.1182/blood.V74.2.537.537

Arora N, Anbalagan LC, Pannu AK. Towards Eradication of Malaria: Is the WHO’s RTS,S/AS01 Vaccination Effective Enough?. Risk Manag Healthc Policy 2021;14:1033-9. https://doi.org/10.2147/RMHP

Alonso PL, Smith TA, Armstrong-Schellenberg JRM, Kitua AY, Masanja H, Hayes R, et al. Duration of Protection and Age-Dependence of the Effects of the SPf66 Malaria Vaccine in African Children Exposed to Intense Transmission of Plasmodium falciparum. J Infect Dis 1996;174:367-72. https://doi.org/10.1093/infdis/174.2.367