New antibiotics against bacterial resistance

Lorena Liseth Cárdenas, Maritza Angarita Merchán, Diana Paola López

Resumen


The evolution of bacterial resistance is generating a serious public health problem due to the indiscriminate use of antibiotics, the application of non-optimal doses, the irregularity in the taking of medicines sent by the health professional, factors that have affected the increase in the rate of antimicrobial resistance; It is important to generate strategies that contribute to diminishing it, including the rational use of antibiotics and the constant research of new therapeutic alternatives such as teixobactin, which is a product of the Gram negative bacterium called Eleftheria terrae, related to the genus Aquabacterium, is a microorganism that presents extremophile conditions, for which, a multichannel system of semipermeable membranes called Ichip was developed for its isolation. Eravacycline is a new fully synthetic bacteriostatic antibiotic of the tetracycline family, is a potent inhibitor based on the mechanism of the bacterial ribosome and exerts potent activity against a broad spectrum of susceptible and multiresistant bacteria.


Palabras clave


Teixobactin; eravacycline; tetracycline; bacterial resistance; lipid II; Eleftheria Terrae; Ichip.

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DOI: http://dx.doi.org/10.22354/in.v23i4.807

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