Evaluación del panel BioFire Filmarray para patógenos respiratorios: un análisis demográfico y clínico en Estambul, Turquía
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Nuestro objetivo fue analizar la distribución de patógenos respiratorios (RP) detectados por un método basado en PCR multiplex (BioFire Diagnostics, EE. UU.) entre pacientes con sospecha de infecciones del tracto respiratorio (ITR) y evaluar las características demográficas, clínicas y radiológicas de los individuos infectados. Se detectaron RP en 1621/6376 (25,4%) de las muestras en los años 2018-2020. Los rinovirus/enterovirus (RV/EV) fueron los patógenos detectados con mayor frecuencia (38,1 %), seguidos de los virus de la influenza A y B (21 %) y el virus de la parainfluenza (PIV) (9,5 %). Se detectó un solo patógeno en 1361 (84%) y múltiples patógenos en 260 (16%) de 1621 muestras. Al menos una comorbilidad estaba presente en 379 (30,5%) de los pacientes. La fiebre fue el signo más frecuente seguido de tos y disnea. La TC de tórax estuvo presente en 426 de 1243 pacientes positivos para RP (34,3%). Cualquier hallazgo radiológico se encontró significativamente relacionado con un patógeno específico. No se administró medicación al 52,9%, mientras que al 35,7% se le administraron antibióticos y al 3,8% antivirales. El panel Film Array como una prueba de PCR multiplex no se usa racionalmente en nuestro hospital y los resultados no mejoraron drásticamente el manejo de las ITR. Se requiere una mejor comunicación entre el médico y el microbiólogo para el uso eficiente del laboratorio y el uso racional de los antimicrobianos.
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